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Crystal structure of pdgfra kinase domain mutant T674I

Analyse Crystal structure of pdgfra kinase domain mutant T674I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6A32
Type: protein
Length: 336 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Platelet-derived growth factor receptor alpha
EC: 2.7.10.1
UniProt: P16234
Pockets: 5 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Platelet-derived growth factor receptor alpha (EC 2.7.10.1)	protein	336	43% helix, 20% strand	P16234

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	216	0.64	0.83	46	empty
2	176	0.60	0.83	28	empty
3	323	0.58	0.76	34	empty
4	78	0.41	0.79	18	empty
5	82	0.34	0.75	24	empty

Compared structures

6A32 · Crystal structure of PDGFRA kinase domain mutant T674I · the same entry in another collection · chain A against A, TM-score 1.00
P16234 · AlphaFold monomer V2.0 prediction for platelet-derived growth factor receptor alpha… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16234
Elsewhere: RCSB PDB 6A32 · PDBe 6A32 · UniProt P16234

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