UniProt P16234
Platelet-derived growth factor receptor alpha (P16234)
Platelet-derived growth factor receptor alpha (UniProt P16234), EC 2.7.10.1: 17 experimental structures on GenesisL1, 8 ligands bound, 21 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P16234
- Protein
- Platelet-derived growth factor receptor alpha
- EC
- 2.7.10.1
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 21 · 5 records with a druggable one
Structures
17 records of P16234 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GRN | Crystal structure of PDGFRA in Complex with WQ-C-159 | x-ray diffraction | A | 748, CL | 1 (best 0.74) |
| 5GRN | Crystal structure of pdgfra in complex with wq-C-159 | x-ray diffraction | A | — | — |
| 5K5X | Crystal structure of human PDGFRA | x-ray diffraction | A | SO4 | 4 (best 0.59) |
| 5K5X | Crystal structure of human pdgfra | x-ray diffraction | A | SO4 | — |
| 6A32 | Crystal structure of pdgfra kinase domain mutant T674I | x-ray diffraction | A | — | — |
| 6JOI | Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization | x-ray diffraction | A | 6T2 | — |
| 6JOI | Crystal structure of pdgfra T674I in complex with crenolanib by co- crystallization | x-ray diffraction | A | 6T2 | — |
| 6JOJ | Crystal structure of pdgfra T674I in complex with crenolanib by soaking | x-ray diffraction | A | 6T2, SO4, CL | — |
| 6JOK | Crystal structure of PDGFRA in complex with sunitinib by soaking | x-ray diffraction | A | B49, CL | — |
| 6JOK | Crystal structure of pdgfra in complex with sunitinib by soaking | x-ray diffraction | A | B49, CL | — |
| 6JOL | Crystal structure of pdgfra in complex with imatinib by co- crystallization | x-ray diffraction | A | STI | — |
| 7LBF | CryoEM structure of the HCMV Trimer gHgLgO in complex with human Platelet-derived growth factor… | electron microscopy | D | NAG | 5 (best 0.72) |
| 7LBF | Cryoem structure of the hcmv trimer ghglgo in complex with human platelet-derived growth factor… | electron microscopy | D | NAG | — |
| 7RAM | Cryo-EM Structure of the HCMV gHgLgO Trimer Derived from AD169 and TR strains in complex with… | electron microscopy | D | — | 9 (best 0.72) |
| 7RAM | Cryo-EM structure of the hcmv ghglgo trimer derived from AD169 and tr strains in complex with… | electron microscopy | D | — | — |
| 8PQH | PDGFRA T674I mutant kinase domain in complex with avapritinib | x-ray diffraction | A | 9JI | 2 (best 0.69) |
| P16234 | AlphaFold monomer V2.0 prediction for platelet-derived growth factor receptor alpha (P16234) | — | — | — |
Ligands
- CL · Chloride ion · in 4 records
- 6T2 · 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine · in 3 records
- SO4 · Sulfate ion · in 3 records
- B49 · N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- 748 · N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide · in 1 record
- 9JI · Avapritinib · in 1 record
- STI · 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide · in 1 record
Elsewhere
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