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SIR2 homologue H80N mutant-ADP ribose complex

Analyse SIR2 homologue H80N mutant-ADP ribose complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1M2J
Type: protein
Length: 249 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Silent information regulator 2
UniProt: O28597
Ligands: APR, ZN
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Silent information regulator 2	protein	249	41% helix, 18% strand	O28597

Ligands and binding sites

APR · Adenosine-5-diphosphoribose · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	374	0.77	0.87	54	APR
2	77	0.30	0.73	19	empty

Compared structures

1M2J · Sir2 homologue H80N mutant-ADP ribose complex · the same entry in another collection · chain A against A, TM-score 1.00
O28597 · AlphaFold monomer V2.0 prediction for NAD-dependent protein deacylase 1 (O28597) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O28597
Elsewhere: RCSB PDB 1M2J · PDBe 1M2J · UniProt O28597

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