UniProt O28597
Silent Information Regulator 2 (O28597)
Silent Information Regulator 2 (UniProt O28597): 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O28597
- Protein
- Silent Information Regulator 2
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 18 · 7 records with a druggable one
Structures
15 records of O28597 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ICI | Crystal structure of a SIR2 homolog-NAD complex | x-ray diffraction | A, B | ZN, NAD | 4 (best 0.72) |
| 1ICI | Crystal structure of a SIR2 homolog-NAD complex | x-ray diffraction | A, B | — | — |
| 1M2G | Sir2 homologue-ADP ribose complex | x-ray diffraction | A | ZN, APR | 2 (best 0.77) |
| 1M2G | SIR2 homologue-ADP ribose complex | x-ray diffraction | A | — | — |
| 1M2H | Sir2 homologue S24A mutant-ADP ribose complex | x-ray diffraction | A | ZN, APR | 2 (best 0.79) |
| 1M2H | SIR2 homologue S24A mutant-ADP ribose complex | x-ray diffraction | A | — | — |
| 1M2J | Sir2 homologue H80N mutant-ADP ribose complex | x-ray diffraction | A | ZN, APR | 2 (best 0.77) |
| 1M2J | SIR2 homologue H80N mutant-ADP ribose complex | x-ray diffraction | A | — | — |
| 1M2K | Sir2 homologue F159A mutant-ADP ribose complex | x-ray diffraction | A | ZN, APR | 2 (best 0.68) |
| 1M2K | SIR2 homologue F159A mutant-ADP ribose complex | x-ray diffraction | A | — | — |
| 1M2N | Sir2 homologues (D102G/F159A/R170A) mutant-2'-O-acetyl ADP ribose complex | x-ray diffraction | A, B | ZN, OAD | 4 (best 0.76) |
| 1M2N | SIR2 homologues (D102G/F159A/R170A) mutant-2'-O-acetyl ADP ribose complex | x-ray diffraction | A, B | — | — |
| 4TWI | The structure of Sir2Af1 bound to a succinylated histone peptide | x-ray diffraction | A | — | — |
| 4TWI | The structure of SIR2AF1 bound to a succinylated histone peptide | x-ray diffraction | A | — | — |
| O28597 | AlphaFold monomer V2.0 prediction for NAD-dependent protein deacylase 1 (O28597) | predicted | A | — | 2 (best 0.73) |
Ligands
Experiment against prediction
- 1M2H chain A against the predicted model O28597: TM-score 0.98, RMSD 0.24 Å
- 1M2H chain A against the predicted model O28597: TM-score 0.98, RMSD 0.24 Å
- 1M2J chain A against the predicted model O28597: TM-score 0.98, RMSD 0.26 Å
- 1M2J chain A against the predicted model O28597: TM-score 0.98, RMSD 0.26 Å
- 1M2K chain A against the predicted model O28597: TM-score 0.98, RMSD 0.27 Å
- 1M2K chain A against the predicted model O28597: TM-score 0.98, RMSD 0.27 Å
- 1M2G chain A against the predicted model O28597: TM-score 0.98, RMSD 0.30 Å
- 1M2G chain A against the predicted model O28597: TM-score 0.98, RMSD 0.30 Å
- 1M2N chain A against the predicted model O28597: TM-score 0.96, RMSD 1.23 Å
- 1M2N chain A against the predicted model O28597: TM-score 0.96, RMSD 1.23 Å
Elsewhere
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