Research workbench

Spcomt apo structure

Analyse Spcomt apo structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ZY5
Type: protein
Length: 481 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable catechol O-methyltransferase 1
EC: 2.1.1.6
UniProt: O42898
Pockets: 4 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable catechol O-methyltransferase 1 (EC 2.1.1.6)	protein	241	46% helix, 19% strand	O42898
B	Probable catechol O-methyltransferase 1 (EC 2.1.1.6)	protein	240	48% helix, 19% strand	O42898

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.49	0.78	29	empty
2	101	0.45	0.79	19	empty
3	125	0.40	0.75	24	empty
4	75	0.37	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 297 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5ZY5 · spCOMT apo structure · the same entry in another collection · chain A against A, TM-score 1.00
O42898 · AlphaFold monomer V2.0 prediction for probable catechol O-methyltransferase 1 (O42898) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O42898
Elsewhere: RCSB PDB 5ZY5 · PDBe 5ZY5 · UniProt O42898

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.