UniProt O42898
Probable catechol O-methyltransferase 1 (O42898)
Probable catechol O-methyltransferase 1 (UniProt O42898), EC 2.1.1.6: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O42898
- Protein
- Probable catechol O-methyltransferase 1
- EC
- 2.1.1.6
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 1 record with a druggable one
Structures
5 records of O42898 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZY5 | spCOMT apo structure | x-ray diffraction | A, B | — | 4 (best 0.49) |
| 5ZY5 | Spcomt apo structure | x-ray diffraction | A, B | — | — |
| 5ZY6 | catechol methyltransferase spCOMT | x-ray diffraction | A, B | SAM | 4 (best 0.65) |
| 5ZY6 | Catechol methyltransferase spcomt | x-ray diffraction | A, B | — | — |
| O42898 | AlphaFold monomer V2.0 prediction for probable catechol O-methyltransferase 1 (O42898) | predicted | A | — | — |
Ligands
- SAM · S-adenosylmethionine · in 1 record
Experiment against prediction
- 5ZY5 chain B against the predicted model O42898: TM-score 0.99, RMSD 0.58 Å
- 5ZY5 chain B against the predicted model O42898: TM-score 0.99, RMSD 0.58 Å
- 5ZY6 chain A against the predicted model O42898: TM-score 0.99, RMSD 0.61 Å
- 5ZY5 chain A against the predicted model O42898: TM-score 0.99, RMSD 0.62 Å
- 5ZY5 chain A against the predicted model O42898: TM-score 0.99, RMSD 0.62 Å
- 5ZY6 chain B against the predicted model O42898: TM-score 0.99, RMSD 0.66 Å
- 5ZY6 chain A against the predicted model O42898: TM-score 0.99, RMSD 0.61 Å
- 5ZY6 chain B against the predicted model O42898: TM-score 0.98, RMSD 0.66 Å
Elsewhere
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