Research workbench
Structure of the human homo-hexameric LRRC8A channel at 4.25 ångströms
Analyse Structure of the human homo-hexameric LRRC8A channel at 4.25 ångströms in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZSU
- Type
- protein
- Length
- 4,227 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Volume-regulated anion channel subunit LRRC8A
- UniProt
- Q8IWT6
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 44% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Volume-regulated anion channel subunit LRRC8A | protein | 707 | 44% helix, 9% strand | Q8IWT6 |
| B, D, F | Volume-regulated anion channel subunit LRRC8A | protein | 702 | 44% helix, 9% strand | Q8IWT6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.83 | 0.84 | 121 | empty |
| 2 | 1007 | 0.83 | 0.84 | 128 | empty |
| 3 | 628 | 0.80 | 0.85 | 60 | empty |
| 4 | 629 | 0.79 | 0.84 | 55 | empty |
| 5 | 651 | 0.79 | 0.84 | 55 | empty |
Interfaces
6 interfaces between chains.
- C–D · 3084 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 3060 Ų buried · 18 hydrogen bonds · protein-protein
- E–F · 3038 Ų buried · 17 hydrogen bonds · protein-protein
- D–E · 1426 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1422 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 5ZSU · Structure of the human homo-hexameric LRRC8A channel at 4.25 Angstroms · the same entry in another collection · chain F against F, TM-score 1.00
- Q8IWT6 · AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A… · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IWT6
- Elsewhere: RCSB PDB 5ZSU · PDBe 5ZSU · UniProt Q8IWT6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.