UniProt Q8IWT6
Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A (Q8IWT6)
Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A (UniProt Q8IWT6): 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 140 pockets. Binding sites…
- UniProt
- Q8IWT6
- Protein
- Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel…
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 140 · 7 records with a druggable one
Structures
11 records of Q8IWT6 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZSU | Structure of the human homo-hexameric LRRC8A channel at 4.25 Angstroms | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.83) |
| 5ZSU | Structure of the human homo-hexameric LRRC8A channel at 4.25 ångströms | electron microscopy | A, B, C, D, E, F | — | — |
| 6DJB | Structure of human Volume Regulated Anion Channel composed of SWELL1 (LRRC8A) | electron microscopy | A, B, E, F, C, D | — | — |
| 6DJB | Structure of human volume regulated anion channel composed of SWELL1 (LRRC8A) | electron microscopy | A, B, E, F, C, D | — | — |
| 7XZH | Cryo-EM structure of human LRRC8A | electron microscopy | A, B, C, D, E, F | P5S, POV, CLR | 20 (best 0.82) |
| 8DXN | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 1 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.68) |
| 8DXO | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 2 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.68) |
| 8DXP | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 3 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.82) |
| 8DXQ | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 4 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.79) |
| 8DXR | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 5 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.78) |
| Q8IWT6 | AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A (Q8IWT6) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8DXO chain F against the predicted model Q8TDW0: TM-score 0.98, RMSD 0.96 Å
- 8DXN chain C against the predicted model Q8TDW0: TM-score 0.98, RMSD 1.02 Å
- 8DXO chain C against the predicted model Q8TDW0: TM-score 0.98, RMSD 1.03 Å
- 8DXQ chain G against the predicted model Q8TDW0: TM-score 0.98, RMSD 1.03 Å
- 8DXN chain F against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.07 Å
- 8DXQ chain F against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.09 Å
- 8DXR chain G against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.08 Å
- 8DXO chain G against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.09 Å
- 8DXP chain F against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.12 Å
- 8DXR chain A against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.12 Å
Elsewhere
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