Research workbench
Crystal structure of human SMAD2-MAN1 complex
Analyse Crystal structure of human SMAD2-MAN1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZOJ
- Type
- protein
- Length
- 801 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mothers against decapentaplegic homolog 2; Inner nuclear membrane protein MAN1
- UniProt
- Q15796, Q9Y2U8
- Pockets
- 7 · best druggability 0.84
Structure
x-ray diffraction · 5 distinct chains · 28% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mothers against decapentaplegic homolog 2 | protein | 187 | 29% helix, 30% strand | Q15796 |
| B | Mothers against decapentaplegic homolog 2 | protein | 185 | 28% helix, 31% strand | Q15796 |
| C | Mothers against decapentaplegic homolog 2 | protein | 186 | 29% helix, 31% strand | Q15796 |
| D | Inner nuclear membrane protein MAN1 | protein | 127 | 29% helix, 24% strand | Q9Y2U8 |
| E | Inner nuclear membrane protein MAN1 | protein | 116 | 22% helix, 26% strand | Q9Y2U8 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1064 | 0.84 | 0.85 | 96 | empty |
| 2 | 292 | 0.62 | 0.80 | 36 | empty |
| 3 | 343 | 0.61 | 0.78 | 32 | empty |
| 4 | 231 | 0.58 | 0.79 | 30 | empty |
| 5 | 166 | 0.48 | 0.77 | 27 | empty |
Interfaces
5 interfaces between chains.
- A–B · 833 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 816 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 790 Ų buried · 14 hydrogen bonds · protein-protein
- B–E · 621 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 615 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5ZOJ · Crystal structure of human SMAD2-MAN1 complex · the same entry in another collection · chain E against E, TM-score 1.00
- Q15796 · AlphaFold monomer V2.0 prediction for mothers against decapentaplegic homolog 2 (Q15796) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9Y2U8 · AlphaFold monomer V2.0 prediction for inner nuclear membrane protein MAN1 (Q9Y2U8) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15796
- Every structure of UniProt Q9Y2U8
- Elsewhere: RCSB PDB 5ZOJ · PDBe 5ZOJ · UniProt Q15796 · UniProt Q9Y2U8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.