Research workbench
Crystal structure of the CRTC2-creb-cre complex
Analyse Crystal structure of the CRTC2-creb-cre complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZKO
- Type
- protein + DNA
- Length
- 233 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclic AMP-responsive element-binding protein 1; DNA (5'…
- UniProt
- P16220, Q3U182
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Cyclic AMP-responsive element-binding protein 1 | protein | 53 | 94% helix, 0% strand | P16220 |
| B, D | DNA (5'- D(*CP*TP*TP*GP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*CP*AP*AP*G)-3') | dna | 20 | — | — |
| G | Creb-regulated transcription coactivator 2 | protein | 43 | 77% helix, 0% strand | Q3U182 |
| H | Creb-regulated transcription coactivator 2 | protein | 44 | 75% helix, 0% strand | Q3U182 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 462 | 0.78 | 0.86 | 41 | empty |
| 2 | 208 | 0.50 | 0.76 | 17 | empty |
| 3 | 126 | 0.42 | 0.76 | 13 | empty |
| 4 | 93 | 0.36 | 0.76 | 12 | empty |
| 5 | 105 | 0.35 | 0.74 | 12 | empty |
Interfaces
15 interfaces between chains.
- A–G · 953 Ų buried · 7 hydrogen bonds · protein-protein
- C–H · 908 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 897 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 897 Ų buried · 85 hydrogen bonds · nucleic-nucleic
- A–H · 512 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5ZKO · Crystal structure of the CRTC2-CREB-CRE complex · the same entry in another collection · chain H against H, TM-score 1.00
- Q3U182 · AlphaFold monomer V2.0 prediction for creb-regulated transcription coactivator 2 (Q3U182) · a predicted model of the same protein · chain G against A, TM-score 0.94
- P16220 · AlphaFold monomer V2.0 prediction for cyclic AMP-responsive element- binding protein 1… · a predicted model of the same protein · chain C against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16220
- Every structure of UniProt Q3U182
- Elsewhere: RCSB PDB 5ZKO · PDBe 5ZKO · UniProt P16220 · UniProt Q3U182
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