Research workbench
Crystal structure of the CRTC2(SEMET)-creb-cre complex
Analyse Crystal structure of the CRTC2(SEMET)-creb-cre complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ZK1
- Type
- protein + DNA
- Length
- 112 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*CP*TP*TP*GP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*CP*AP*AP*G)-3'); Cyclic…
- UniProt
- P16220, Q3U182
- Ligands
- ZN
Structure
x-ray diffraction · 3 distinct chains · 89% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'- D(*CP*TP*TP*GP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*CP*AP*AP*G)-3') | dna | 20 | — | — |
| A | Cyclic AMP-responsive element-binding protein 1 | protein | 53 | 96% helix, 0% strand | P16220 |
| C | Creb-regulated transcription coactivator 2 | protein | 39 | 79% helix, 0% strand | Q3U182 |
Ligands and binding sites
- ZN · Zinc ion · metal
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
3 interfaces between chains.
- A–C · 839 Ų buried · 8 hydrogen bonds · protein-protein
- B–A · 367 Ų buried · 6 hydrogen bonds · protein-nucleic
- B–C · 70 Ų buried · 1 hydrogen bond · protein-nucleic
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 5ZK1 · Crystal Structure of the CRTC2(SeMet)-CREB-CRE complex · the same entry in another collection · chain B against B, TM-score 1.00
- P16220 · AlphaFold monomer V2.0 prediction for cyclic AMP-responsive element- binding protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.90
- Q3U182 · AlphaFold monomer V2.0 prediction for creb-regulated transcription coactivator 2 (Q3U182) · a predicted model of the same protein · chain C against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16220
- Every structure of UniProt Q3U182
- Elsewhere: RCSB PDB 5ZK1 · PDBe 5ZK1 · UniProt P16220 · UniProt Q3U182
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