Research workbench
Structure of TIRR/53BP1 complex
Analyse Structure of TIRR/53BP1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Z78
- Type
- protein
- Length
- 517 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tudor-interacting repair regulator protein; TP53-binding protein 1
- UniProt
- Q8VHN8, Q12888
- Pockets
- 7 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 28% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Tudor-interacting repair regulator protein | protein | 197 | 35% helix, 32% strand | Q8VHN8 |
| A | Tudor-interacting repair regulator protein | protein | 199 | 32% helix, 32% strand | Q8VHN8 |
| C | TP53-binding protein 1 | protein | 121 | 9% helix, 44% strand | Q12888 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1098 | 0.74 | 0.77 | 101 | empty |
| 2 | 55 | 0.72 | 0.99 | 20 | empty |
| 3 | 250 | 0.55 | 0.77 | 36 | empty |
| 4 | 101 | 0.42 | 0.77 | 17 | empty |
| 5 | 67 | 0.37 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–A · 1503 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 673 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5Z78 · Structure of TIRR/53BP1 complex · the same entry in another collection · chain B against B, TM-score 1.00
- Q8VHN8 · AlphaFold monomer V2.0 prediction for tudor-interacting repair regulator protein (Q8VHN8) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q12888 · AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VHN8
- Every structure of UniProt Q12888
- Elsewhere: RCSB PDB 5Z78 · PDBe 5Z78 · UniProt Q8VHN8 · UniProt Q12888
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