Research workbench
Structural basis of the improved sweetness and stability of the single-chain sweet-tasting protein monellin (mnei)
Analyse Structural basis of the improved sweetness and stability of the single-chain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Z1P
- Type
- protein
- Length
- 366 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monellin chain B,MONELLIN chain a
- UniProt
- P02882, P02881
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monellin chain B,MONELLIN chain a | protein | 95 | 18% helix, 51% strand | P02882, P02881 |
| B, C | Monellin chain B,MONELLIN chain a | protein | 90 | 19% helix, 52% strand | P02882, P02881 |
| D | Monellin chain B,MONELLIN chain a | protein | 91 | 19% helix, 53% strand | P02882, P02881 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.63 | 0.80 | 38 | empty |
| 2 | 104 | 0.34 | 0.74 | 19 | empty |
| 3 | 50 | 0.24 | 0.72 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 482 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 288 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 162 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5Z1P · Structural basis of the improved sweetness and stability of the single-chain… · the same entry in another collection · chain A against A, TM-score 1.00
- P02882 · AlphaFold monomer V2.0 prediction for monellin chain B (P02882) · a predicted model of the same protein · chain B against A, TM-score 0.51
- P02881 · AlphaFold monomer V2.0 prediction for monellin chain a (P02881) · a predicted model of the same protein · chain D against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02882
- Every structure of UniProt P02881
- Elsewhere: RCSB PDB 5Z1P · PDBe 5Z1P · UniProt P02882 · UniProt P02881
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