Research workbench
Crystal structure of fructokinase double-mutant (T261C-H108C) from vibrio cholerae O395 in fructose, ADP and potassium ion bound form
Analyse Crystal structure of fructokinase double-mutant (T261C-H108C) from vibrio… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5YGG
- Type
- protein
- Length
- 310 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructokinase
- EC
- 2.7.1.4
- UniProt
- A0A0H3AER7
- Ligands
- ADP, FRU, CA, K
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructokinase (EC 2.7.1.4) | protein | 310 | 42% helix, 23% strand | A0A0H3AER7 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- FRU · beta-D-fructofuranose · sugar · chains A
- CA · Calcium ion · metal · chains A
- K · Potassium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 461 | 0.72 | 0.82 | 61 | ADP, FRU, CA |
| 2 | 86 | 0.46 | 0.81 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5YGG · Crystal structure of Fructokinase Double-Mutant (T261C-H108C) from Vibrio cholerae O395… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H3AER7
- Elsewhere: RCSB PDB 5YGG · PDBe 5YGG · UniProt A0A0H3AER7
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