Research workbench
Crystal structure of KU70/80 and TLC1
Analyse Crystal structure of KU70/80 and TLC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5Y58
- Type
- protein + RNA
- Length
- 3,427 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent DNA helicase II subunit 1; ATP-dependent DNA helicase II subunit 2; TLC1
- EC
- 3.6.4.12
- UniProt
- P32807, Q04437
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 5 distinct chains · 32% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | ATP-dependent DNA helicase II subunit 1 (EC 3.6.4.12) | protein | 548 | 38% helix, 24% strand | P32807 |
| B | ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) | protein | 568 | 30% helix, 26% strand | Q04437 |
| X, Y, Z | TLC1 | rna | 30 | — | — |
| D | ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) | protein | 560 | 30% helix, 26% strand | Q04437 |
| F | ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) | protein | 565 | 30% helix, 26% strand | Q04437 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 984 | 0.85 | 0.86 | 95 | empty |
| 2 | 933 | 0.84 | 0.86 | 91 | empty |
| 3 | 907 | 0.84 | 0.86 | 92 | empty |
| 4 | 899 | 0.84 | 0.86 | 83 | empty |
| 5 | 891 | 0.83 | 0.85 | 80 | empty |
Interfaces
21 interfaces between chains.
- E–F · 11413 Ų buried · 164 hydrogen bonds · protein-protein
- A–B · 11379 Ų buried · 160 hydrogen bonds · protein-protein
- C–D · 11376 Ų buried · 154 hydrogen bonds · protein-protein
- D–Y · 989 Ų buried · 23 hydrogen bonds · protein-nucleic
- F–Z · 988 Ų buried · 24 hydrogen bonds · protein-nucleic
Compared structures
- 5Y58 · Crystal structure of Ku70/80 and TLC1 · the same entry in another collection · chain Y against Y, TM-score 1.00
- P32807 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase II subunit 1 (P32807) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q04437 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase II subunit 2 (Q04437) · a predicted model of the same protein · chain F against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32807
- Every structure of UniProt Q04437
- Elsewhere: RCSB PDB 5Y58 · PDBe 5Y58 · UniProt P32807 · UniProt Q04437
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.