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Crystal structure of daxx helical bundle domain in complex with atrx

Analyse Crystal structure of daxx helical bundle domain in complex with atrx in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5Y18
Type
protein
Length
102 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Death domain-associated protein 6; Transcriptional regulator atrx
EC
3.6.4.12
UniProt
Q9UER7, P46100

Structure

x-ray diffraction · 2 distinct chains · 79% helix, 2% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADeath domain-associated protein 6protein8578% helix, 2% strandQ9UER7
BTranscriptional regulator atrx (EC 3.6.4.12)protein1788% helix, 0% strandP46100

Interfaces

1 interface between chains.

  • A–B · 580 Ų buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

  • 5Y18 · Crystal structure of DAXX helical bundle domain in complex with ATRX · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9UER7 · AlphaFold monomer V2.0 prediction for death domain-associated protein 6 (Q9UER7) · a predicted model of the same protein · chain A against A, TM-score 0.94
  • P46100 · AlphaFold monomer V2.0 prediction for transcriptional regulator atrx (P46100) · a predicted model of the same protein · chain B against A, TM-score 0.86

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