UniProt P46100
Transcriptional regulator ATRX (P46100)
Transcriptional regulator ATRX (UniProt P46100), EC 3.6.4.12: 23 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P46100
- Protein
- Transcriptional regulator ATRX
- EC
- 3.6.4.12
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 1
Structures
24 records of P46100 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JM1 | Structures and chemical shift assignments for the ADD domain of the ATRX protein | solution nmr | A | — | — |
| 2JM1 | Structures and chemical shift assignments for the add domain of the atrx protein | solution nmr | A | — | — |
| 2LBM | Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3 | solution nmr | A | — | — |
| 2LBM | Solution structure of the add domain of atrx complexed with histone tail H3 1-15 K9ME3 | solution nmr | A | — | — |
| 2LD1 | Structures and chemical shift assignments for the ADD domain of the ATRX protein | solution nmr | A | — | — |
| 2LD1 | Structures and chemical shift assignments for the add domain of the atrx protein | solution nmr | A | — | — |
| 3QL9 | Monoclinic complex structure of ATRX ADD bound to histone H3K9me3 peptide | x-ray diffraction | A | — | — |
| 3QL9 | Monoclinic complex structure of atrx add bound to histone H3K9ME3 peptide | x-ray diffraction | A | — | — |
| 3QLA | Hexagonal complex structure of ATRX ADD bound to H3K9me3 peptide | x-ray diffraction | A, D | — | — |
| 3QLA | Hexagonal complex structure of atrx add bound to H3K9ME3 peptide | x-ray diffraction | A, D | — | — |
| 3QLC | Complex structure of ATRX ADD domain bound to unmodified H3 1-15 peptide | x-ray diffraction | A, B | — | — |
| 3QLC | Complex structure of atrx add domain bound to unmodified H3 1-15 peptide | x-ray diffraction | A, B | — | — |
| 3QLN | Crystal structure of ATRX ADD domain in free state | x-ray diffraction | A, B | — | — |
| 3QLN | Crystal structure of atrx add domain in free state | x-ray diffraction | A, B | — | — |
| 4W5A | Complex structure of ATRX ADD bound to H3K9me3S10ph peptide | x-ray diffraction | A, B, E | — | — |
| 4W5A | Complex structure of atrx add bound to H3K9ME3S10PH peptide | x-ray diffraction | A, B, E | — | — |
| 5GRQ | Crystal Structure of DHB domain of Daxx in complex with an ATRX peptide | x-ray diffraction | C, D | ZN | — |
| 5GRQ | Crystal structure of dhb domain of daxx in complex with an atrx peptide | x-ray diffraction | C, D | — | — |
| 5Y18 | Crystal structure of DAXX helical bundle domain in complex with ATRX | x-ray diffraction | B | — | — |
| 5Y18 | Crystal structure of daxx helical bundle domain in complex with atrx | x-ray diffraction | B | — | — |
| 5Y6O | Crystal structure of DAXX N-terminal four-helix bundle domain (4HB) in complex with ATRX | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 5Y6O | Crystal structure of daxx N-terminal four-helix bundle domain (4HB) in complex with atrx | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 6G0O | Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated atrx peptide… | x-ray diffraction | B | — | — |
| P46100 | AlphaFold monomer V2.0 prediction for transcriptional regulator atrx (P46100) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 3QLN chain B against the predicted model P46100: TM-score 0.98, RMSD 0.62 Å
- 3QLN chain B against the predicted model P46100: TM-score 0.98, RMSD 0.62 Å
- 3QLN chain A against the predicted model P46100: TM-score 0.98, RMSD 0.66 Å
- 3QLN chain A against the predicted model P46100: TM-score 0.98, RMSD 0.66 Å
- 4W5A chain E against the predicted model P46100: TM-score 0.96, RMSD 0.83 Å
- 4W5A chain E against the predicted model P46100: TM-score 0.96, RMSD 0.83 Å
- 3QLA chain D against the predicted model P46100: TM-score 0.95, RMSD 1.00 Å
- 3QLA chain D against the predicted model P46100: TM-score 0.95, RMSD 1.00 Å
- 3QL9 chain A against the predicted model P46100: TM-score 0.94, RMSD 1.23 Å
- 3QL9 chain A against the predicted model P46100: TM-score 0.94, RMSD 1.23 Å
Elsewhere
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