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Cryo-EM structure of P300-P53 protein complex

Analyse Cryo-EM structure of P300-P53 protein complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XZC
Type: protein
Length: 1,547 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone acetyltransferase P300; Cellular tumor antigen P53
EC: 2.3.1.48
UniProt: Q09472, P04637
Pockets: 1 · best druggability 0.28

Structure

electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone acetyltransferase P300 (EC 2.3.1.48)	protein	619	0% helix, 0% strand	Q09472
B, C, D, E	Cellular tumor antigen P53	protein	232	0% helix, 0% strand	P04637

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.28	0.73	17	empty

Interfaces

5 interfaces between chains.

B–D · 170 Å² buried · 0 hydrogen bonds · protein-protein
C–E · 170 Å² buried · 0 hydrogen bonds · protein-protein
D–E · 97 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 64 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 53 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5XZC · Cryo-EM structure of p300-p53 protein complex · the same entry in another collection · chain C against C, TM-score 1.00
Q09472 · AlphaFold monomer V2.0 prediction for histone acetyltransferase P300 (Q09472) · a predicted model of the same protein · chain A against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q09472
Every structure of UniProt P04637
Elsewhere: RCSB PDB 5XZC · PDBe 5XZC · UniProt Q09472 · UniProt P04637

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