Research workbench
Monomer form of M.TUBERCULOSIS pkni sensor domain
Analyse Monomer form of M.TUBERCULOSIS pkni sensor domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XLM
- Type
- protein
- Length
- 289 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase pkni
- EC
- 2.7.11.1
- UniProt
- P9WI69
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase pkni (EC 2.7.11.1) | protein | 145 | 2% helix, 51% strand | P9WI69 |
| B | SERINE/THREONINE-protein kinase pkni (EC 2.7.11.1) | protein | 144 | 2% helix, 51% strand | P9WI69 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 342 | 0.70 | 0.83 | 33 | empty |
| 2 | 282 | 0.55 | 0.76 | 40 | empty |
| 3 | 173 | 0.54 | 0.79 | 19 | empty |
| 4 | 147 | 0.48 | 0.77 | 18 | empty |
| 5 | 91 | 0.39 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 819 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WI69
- Elsewhere: RCSB PDB 5XLM · PDBe 5XLM · UniProt P9WI69
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