Research workbench

MUTNLIR_LC3B

Analyse MUTNLIR_LC3B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XAE
Type: protein
Length: 499 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated proteins 1A/1B light chain 3B
UniProt: Q9GZQ8
Pockets: 10 · best druggability 0.81

Structure

x-ray diffraction · 4 distinct chains · 29% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Microtubule-associated proteins 1A/1B light chain 3B	protein	123	30% helix, 23% strand	Q9GZQ8
B	Microtubule-associated proteins 1A/1B light chain 3B	protein	123	30% helix, 21% strand	Q9GZQ8
C	Microtubule-associated proteins 1A/1B light chain 3B	protein	126	29% helix, 21% strand	Q9GZQ8
D	Microtubule-associated proteins 1A/1B light chain 3B	protein	127	28% helix, 21% strand	Q9GZQ8

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	966	0.81	0.82	79	empty
2	255	0.62	0.81	33	empty
3	152	0.46	0.76	32	empty
4	117	0.43	0.77	19	empty
5	61	0.41	0.81	15	empty

Interfaces

5 interfaces between chains.

A–B · 944 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 539 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 270 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 263 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 55 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5XAE · mutNLIR_LC3B · the same entry in another collection · chain D against D, TM-score 1.00
Q9GZQ8 · AlphaFold monomer V2.0 prediction for microtubule-associated proteins 1A/1B light chain… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZQ8
Elsewhere: RCSB PDB 5XAE · PDBe 5XAE · UniProt Q9GZQ8

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