Research workbench

CLIR - LC3B

Analyse CLIR - LC3B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XAC
Type: protein
Length: 485 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated proteins 1A/1B light chain 3B
UniProt: Q9GZQ8
Pockets: 10 · best druggability 0.70

Structure

x-ray diffraction · 4 distinct chains · 31% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Microtubule-associated proteins 1A/1B light chain 3B	protein	123	30% helix, 21% strand	Q9GZQ8
B	Microtubule-associated proteins 1A/1B light chain 3B	protein	121	31% helix, 22% strand	Q9GZQ8
C	Microtubule-associated proteins 1A/1B light chain 3B	protein	117	32% helix, 24% strand	Q9GZQ8
D	Microtubule-associated proteins 1A/1B light chain 3B	protein	124	30% helix, 23% strand	Q9GZQ8

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	706	0.70	0.77	53	empty
2	242	0.59	0.79	41	empty
3	173	0.54	0.80	21	empty
4	185	0.54	0.79	27	empty
5	301	0.53	0.75	35	empty

Interfaces

5 interfaces between chains.

A–B · 772 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 627 Å² buried · 7 hydrogen bonds · protein-protein
C–D · 601 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 418 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 202 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5XAC · CLIR - LC3B · the same entry in another collection · chain D against D, TM-score 1.00
Q9GZQ8 · AlphaFold monomer V2.0 prediction for microtubule-associated proteins 1A/1B light chain… · a predicted model of the same protein · chain C against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZQ8
Elsewhere: RCSB PDB 5XAC · PDBe 5XAC · UniProt Q9GZQ8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.