Research workbench
Crystal structure of MAGEG1 and NSE1 complex
Analyse Crystal structure of MAGEG1 and NSE1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WY5
- Type
- protein
- Length
- 425 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Melanoma-associated antigen G1; Non-structural maintenance of chromosomes element 1…
- EC
- 6.3.2.-
- UniProt
- Q96MG7, Q8WV22
- Ligands
- MG, ZN
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Melanoma-associated antigen G1 | protein | 189 | 63% helix, 10% strand | Q96MG7 |
| A | Non-structural maintenance of chromosomes element 1 homolog (EC 6.3.2.-) | protein | 236 | 44% helix, 15% strand | Q8WV22 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 754 | 0.70 | 0.77 | 75 | empty |
| 2 | 113 | 0.61 | 0.86 | 25 | empty |
| 3 | 180 | 0.52 | 0.78 | 30 | empty |
| 4 | 136 | 0.49 | 0.79 | 31 | empty |
Interfaces
1 interface between chains.
- B–A · 1270 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 5WY5 · Crystal structure of MAGEG1 and NSE1 complex · the same entry in another collection · chain B against B, TM-score 1.00
- Q8WV22 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosomes element 1… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q96MG7 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosomes element 3… · a predicted model of the same protein · chain B against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96MG7
- Every structure of UniProt Q8WV22
- Elsewhere: RCSB PDB 5WY5 · PDBe 5WY5 · UniProt Q96MG7 · UniProt Q8WV22
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