Research workbench
Crystal structure of HNRNPA2B1 in complex with RNA
Analyse Crystal structure of HNRNPA2B1 in complex with RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WWF
- Type
- protein + RNA
- Length
- 374 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heterogeneous nuclear ribonucleoproteins A2/B1; RNA
- UniProt
- P22626
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heterogeneous nuclear ribonucleoproteins A2/B1 | protein | 178 | 24% helix, 37% strand | P22626 |
| B, D | RNA | rna | 10 | — | — |
| C | Heterogeneous nuclear ribonucleoproteins A2/B1 | protein | 176 | 22% helix, 38% strand | P22626 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.57 | 0.77 | 30 | empty |
| 2 | 234 | 0.57 | 0.78 | 29 | empty |
| 3 | 65 | 0.31 | 0.75 | 15 | empty |
| 4 | 62 | 0.27 | 0.73 | 13 | empty |
Interfaces
3 interfaces between chains.
- C–D · 629 Ų buried · 20 hydrogen bonds · protein-nucleic
- A–B · 618 Ų buried · 28 hydrogen bonds · protein-nucleic
- A–C · 264 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5WWF · Crystal structure of hnRNPA2B1 in complex with RNA · the same entry in another collection · chain A against A, TM-score 1.00
- P22626 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoproteins A2/B1… · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22626
- Elsewhere: RCSB PDB 5WWF · PDBe 5WWF · UniProt P22626
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