UniProt P22626
Heterogeneous nuclear ribonucleoproteins A2/B1 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (UniProt P22626): 22 experimental structures and 1 predicted model on GenesisL1, 53 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22626
- Protein
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 53 · 12 records with a druggable one
Structures
23 records of P22626 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X4B | Solution structure of RRM domain in Heterogeneous nuclear ribonucleaoproteins A2/B1 | solution nmr | A | — | 1 (best 0.33) |
| 1X4B | Solution structure of rrm domain in heterogeneous nuclear ribonucleaoproteins A2/B1 | solution nmr | A | — | 1 (best 0.33) |
| 5EN1 | Crystal structure of hnRNPA2B1 in complex with RNA | x-ray diffraction | A | — | 1 (best 0.64) |
| 5EN1 | Crystal structure of HNRNPA2B1 in complex with RNA | x-ray diffraction | A | — | 1 (best 0.64) |
| 5HO4 | Crystal structure of hnRNPA2B1 in complex with 10-mer RNA | x-ray diffraction | A | — | 1 (best 0.55) |
| 5HO4 | Crystal structure of HNRNPA2B1 in complex with 10-mer RNA | x-ray diffraction | A | — | 1 (best 0.55) |
| 5WWE | Crystal structure of hnRNPA2B1 in complex with RNA | x-ray diffraction | A | — | 2 (best 0.54) |
| 5WWE | Crystal structure of HNRNPA2B1 in complex with RNA | x-ray diffraction | A | — | — |
| 5WWF | Crystal structure of hnRNPA2B1 in complex with RNA | x-ray diffraction | A, C | — | 4 (best 0.57) |
| 5WWF | Crystal structure of HNRNPA2B1 in complex with RNA | x-ray diffraction | A, C | — | — |
| 5WWG | Crystal structure of hnRNPA2B1 in complex with AAGGACUUGC | x-ray diffraction | A | — | 1 (best 0.64) |
| 5WWG | Crystal structure of HNRNPA2B1 in complex with aaggacuugc | x-ray diffraction | A | — | — |
| 6WPQ | GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | x-ray diffraction | A | — | — |
| 6WPQ | Gnynvf from HNRNPA2-low complexity domain segment, residues 286-291, D290V variant | x-ray diffraction | A | — | — |
| 6WQK | hnRNPA2 Low complexity domain (LCD) determined by cryoEM | electron microscopy | A, B, C, D, E | — | — |
| 6WQK | HNRNPA2 low complexity domain (lcd) determined by cryoem | electron microscopy | A, B, C, D, E | — | — |
| 7WM3 | hnRNP A2/B1 RRMs in complex with single-stranded DNA | x-ray diffraction | A, B, C, D | — | 10 (best 0.81) |
| 7WM3 | Hnrnp A2/B1 rrms in complex with single-stranded DNA | x-ray diffraction | A, B, C, D | — | — |
| 8DU2 | HnRNPA2 D290V LCD PM1 | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 5 (best 0.73) |
| 8DUW | HnRNPA2 D290V LCD PM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 2 (best 0.64) |
| 8EC7 | HnRNPA2 D290V LCD PM3 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | 1 (best 0.38) |
| 8HNI | hnRNP A2/B1 RRMs in complex with telomeric DNA | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.80) |
| P22626 | AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoproteins A2/B1 (P22626) | predicted | A | — | 2 (best 0.65) |
Experiment against prediction
- 8HNI chain H against the predicted model P22626: TM-score 0.98, RMSD 0.73 Å
- 8HNI chain E against the predicted model P22626: TM-score 0.98, RMSD 0.76 Å
- 8HNI chain L against the predicted model P22626: TM-score 0.98, RMSD 0.77 Å
- 8HNI chain G against the predicted model P22626: TM-score 0.98, RMSD 0.77 Å
- 5HO4 chain A against the predicted model P22626: TM-score 0.98, RMSD 0.79 Å
- 5HO4 chain A against the predicted model P22626: TM-score 0.98, RMSD 0.79 Å
- 8HNI chain I against the predicted model P22626: TM-score 0.98, RMSD 0.80 Å
- 8HNI chain J against the predicted model P22626: TM-score 0.98, RMSD 0.81 Å
- 8HNI chain C against the predicted model P22626: TM-score 0.98, RMSD 0.82 Å
- 8HNI chain K against the predicted model P22626: TM-score 0.97, RMSD 0.79 Å
Elsewhere
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