MolNFT v1 · #121198 · protein + RNA

Crystal structure of HNRNPA2B1 in complex with 10-mer RNA

5HO4 · Heterogeneous nuclear ribonucleoproteins A2/B1: “Crystal structure of HNRNPA2B1 in complex with 10-mer RNA”. X-ray diffraction, 1 pocket (best druggability 0.55). MolNFT v1 #121198 on GenesisL1: 3D structure, binding sites and…

PDB: 5HO4
Type: protein + RNA
Length: 188 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heterogeneous nuclear ribonucleoproteins A2/B1; RNA…
UniProt: P22626
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heterogeneous nuclear ribonucleoproteins A2/B1	protein	179	25% helix, 37% strand	P22626
B	RNA (5'-R(APAPGPGPAPCPUPAPGPC)-3')	rna	9	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.55	0.78	23	empty

Interfaces

1 interface between chains.

A–B · 718 Å² buried · 20 hydrogen bonds · protein-nucleic

Compared structures

5HO4 · Crystal structure of hnRNPA2B1 in complex with 10-mer RNA · the same entry in another collection · chain A against A, TM-score 1.00
P22626 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoproteins A2/B1… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22626
Elsewhere: RCSB PDB 5HO4 · PDBe 5HO4 · UniProt P22626

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.