MolNFT v1 · #138847 · protein + RNA

Crystal structure of HNRNPA2B1 in complex with aaggacuugc

5WWG · Heterogeneous nuclear ribonucleoproteins A2/B1: “Crystal structure of HNRNPA2B1 in complex with aaggacuugc”. X-ray diffraction, 1 pocket (best druggability 0.64). MolNFT v1 #138847 on GenesisL1: 3D structure, binding sites and…

PDB: 5WWG
Type: protein + RNA
Length: 192 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heterogeneous nuclear ribonucleoproteins A2/B1; RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*U)-3')
UniProt: P22626
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heterogeneous nuclear ribonucleoproteins A2/B1	protein	184	30% helix, 34% strand	P22626
B	RNA (5'-R(APAPGPGPAPCPUPU)-3')	rna	8	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	287	0.64	0.81	37	empty

Interfaces

1 interface between chains.

A–B · 718 Å² buried · 23 hydrogen bonds · protein-nucleic

Compared structures

5WWG · Crystal structure of hnRNPA2B1 in complex with AAGGACUUGC · the same entry in another collection · chain A against A, TM-score 1.00
P22626 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoproteins A2/B1… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22626
Elsewhere: RCSB PDB 5WWG · PDBe 5WWG · UniProt P22626

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