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Crystal structure of HNRNPA2B1 in complex with RNA

Analyse Crystal structure of HNRNPA2B1 in complex with RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WWE
Type: protein + RNA
Length: 183 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heterogeneous nuclear ribonucleoproteins A2/B1; RNA…
UniProt: P22626
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heterogeneous nuclear ribonucleoproteins A2/B1	protein	174	24% helix, 33% strand	P22626
B	RNA (5'-R(APGPGPGPAPCPUPAPGPA)-3')	rna	9	—	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.54	0.81	30	empty
2	104	0.34	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 616 Å² buried · 22 hydrogen bonds · protein-nucleic

Compared structures

5WWE · Crystal structure of hnRNPA2B1 in complex with RNA · the same entry in another collection · chain A against A, TM-score 1.00
P22626 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoproteins A2/B1… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22626
Elsewhere: RCSB PDB 5WWE · PDBe 5WWE · UniProt P22626

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