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Crystal structure of apo human TUT1, form I

Analyse Crystal structure of apo human TUT1, form I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WU1
Type: protein
Length: 977 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Speckle targeted PIP5K1A-regulated POLY(A) polymerase
EC: 2.7.7.19, 2.7.7.52
UniProt: Q9H6E5
Ligands: CL
Pockets: 12 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Speckle targeted PIP5K1A-regulated POLY(A) polymerase (EC 2.7.7.19, 2.7.7.52)	protein	493	46% helix, 15% strand	Q9H6E5
B	Speckle targeted PIP5K1A-regulated POLY(A) polymerase (EC 2.7.7.19, 2.7.7.52)	protein	484	45% helix, 15% strand	Q9H6E5

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	582	0.69	0.78	46	empty
2	524	0.68	0.79	43	empty
3	277	0.58	0.78	42	empty
4	264	0.58	0.78	42	empty
5	357	0.55	0.74	33	empty

Interfaces

1 interface between chains.

A–B · 527 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5WU1 · Crystal structure of apo human Tut1, form I · the same entry in another collection · chain A against A, TM-score 1.00
Q9H6E5 · AlphaFold monomer V2.0 prediction for speckle targeted PIP5K1A-regulated POLY(A)… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H6E5
Elsewhere: RCSB PDB 5WU1 · PDBe 5WU1 · UniProt Q9H6E5

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