UniProt Q9H6E5
Speckle targeted PIP5K1A-regulated poly(A) polymerase (Q9H6E5)
Speckle targeted PIP5K1A-regulated poly(A) polymerase (UniProt Q9H6E5), EC 2.7.7.19, 2.7.7.52: 16 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 99 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9H6E5
- Protein
- Speckle targeted PIP5K1A-regulated poly(A) polymerase
- EC
- 2.7.7.19, 2.7.7.52
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 99 · 8 records with a druggable one
Structures
17 records of Q9H6E5 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2E5G | Solution structure of RNA binding domain in RNA binding motif protein 21 | solution nmr | A | — | — |
| 2E5G | Solution structure of RNA binding domain in RNA binding motif protein 21 | solution nmr | A | — | — |
| 5WU1 | Crystal structure of apo human Tut1, form I | x-ray diffraction | A, B | CL | 12 (best 0.69) |
| 5WU1 | Crystal structure of apo human TUT1, form I | x-ray diffraction | A, B | CL | — |
| 5WU2 | Crystal structure of human Tut1 bound with BaUTP, form I | x-ray diffraction | A, B | UTP, BA, CL | 12 (best 0.69) |
| 5WU2 | Crystal structure of human TUT1 bound with bautp, form I | x-ray diffraction | A, B | UTP, BA, CL | — |
| 5WU3 | Crystal structure of human Tut1 bound with MgUTP, form II | x-ray diffraction | A, B | UTP, MG, CL | — |
| 5WU3 | Crystal structure of human TUT1 bound with mgutp, form II | x-ray diffraction | A, B | UTP, MG, CL | — |
| 5WU4 | Crystal structure of human Tut1 bound with MgATP, form II | x-ray diffraction | A, B | ATP, MG, CL | 11 (best 0.70) |
| 5WU4 | Crystal structure of human TUT1 bound with mgatp, form II | x-ray diffraction | A, B | ATP, MG, CL | — |
| 5WU5 | Crystal structure of apo human Tut1, form III | x-ray diffraction | A, B, C, D | — | 20 (best 0.77) |
| 5WU5 | Crystal structure of apo human TUT1, form III | x-ray diffraction | A, B, C, D | — | — |
| 5WU6 | Crystal structure of apo human Tut1, form IV | x-ray diffraction | A, B, C, D | MG | 17 (best 0.66) |
| 5WU6 | Crystal structure of apo human TUT1, form IV | x-ray diffraction | A, B, C, D | MG | — |
| 8IDF | Crystal structure of human TUT1 complexed with U6 snRNA | x-ray diffraction | A | ZN | 6 (best 0.79) |
| 9J8P | Cryo-EM structure of human TUT1 complexed with U6 snRNA | electron microscopy | A | ZN | 12 (best 0.64) |
| Q9H6E5 | AlphaFold monomer V2.0 prediction for speckle targeted PIP5K1A-regulated POLY(A) polymerase (Q9H6E5) | predicted | A | — | 9 (best 0.77) |
Ligands
Experiment against prediction
- 5WU1 chain B against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.56 Å
- 5WU1 chain B against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.56 Å
- 5WU2 chain B against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.59 Å
- 5WU2 chain A against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.63 Å
- 5WU2 chain A against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.63 Å
- 5WU4 chain B against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.69 Å
- 5WU4 chain B against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.69 Å
- 5WU3 chain A against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.68 Å
- 5WU3 chain A against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.68 Å
- 5WU4 chain A against the predicted model Q9H6E5: TM-score 0.99, RMSD 0.76 Å
Elsewhere
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