MolNFT v1 · #138786 · protein

Crystal structure of apo human TUT1, form III

5WU5 · Speckle targeted PIP5K1A-regulated POLY(A) polymerase: “Crystal structure of apo human TUT1, form III”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #138786 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 5WU5
Type: protein
Length: 1,936 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Speckle targeted PIP5K1A-regulated POLY(A) polymerase
EC: 2.7.7.19, 2.7.7.52
UniProt: Q9H6E5
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 4 distinct chains · 44% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Speckle targeted PIP5K1A-regulated POLY(A) polymerase (EC 2.7.7.19, 2.7.7.52)	protein	485	44% helix, 15% strand	Q9H6E5
B	Speckle targeted PIP5K1A-regulated POLY(A) polymerase (EC 2.7.7.19, 2.7.7.52)	protein	483	43% helix, 16% strand	Q9H6E5
C	Speckle targeted PIP5K1A-regulated POLY(A) polymerase (EC 2.7.7.19, 2.7.7.52)	protein	485	44% helix, 15% strand	Q9H6E5
D	Speckle targeted PIP5K1A-regulated POLY(A) polymerase (EC 2.7.7.19, 2.7.7.52)	protein	483	45% helix, 15% strand	Q9H6E5

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	942	0.77	0.80	93	empty
2	559	0.74	0.81	71	empty
3	491	0.73	0.82	49	empty
4	608	0.72	0.80	62	empty
5	434	0.68	0.80	48	empty

Interfaces

6 interfaces between chains.

A–B · 1624 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 1339 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 455 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 408 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 374 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5WU5 · Crystal structure of apo human Tut1, form III · the same entry in another collection · chain D against D, TM-score 1.00
Q9H6E5 · AlphaFold monomer V2.0 prediction for speckle targeted PIP5K1A-regulated POLY(A)… · a predicted model of the same protein · chain D against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H6E5
Elsewhere: RCSB PDB 5WU5 · PDBe 5WU5 · UniProt Q9H6E5

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