Research workbench
Complex structure of staphylococcus aureus sdre with human complement factor H
Analyse Complex structure of staphylococcus aureus sdre with human complement factor H in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WTB
- Type
- protein
- Length
- 1,330 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine-aspartate repeat-containing protein E; Peptide from complement factor H
- UniProt
- Q932F7, P08603
- Pockets
- 16 · best druggability 0.73
Structure
x-ray diffraction · 5 distinct chains · 5% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, A | Serine-aspartate repeat-containing protein E | protein | 313 | 5% helix, 51% strand | Q932F7 |
| B | Serine-aspartate repeat-containing protein E | protein | 319 | 6% helix, 53% strand | Q932F7 |
| C | Serine-aspartate repeat-containing protein E | protein | 323 | 4% helix, 53% strand | Q932F7 |
| E, H | Peptide from complement factor H | protein | 17 | 0% helix, 65% strand | P08603 |
| F, G | Peptide from complement factor H | protein | 14 | 0% helix, 50% strand | P08603 |
Pockets
16 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 955 | 0.73 | 0.77 | 84 | empty |
| 2 | 153 | 0.43 | 0.75 | 22 | empty |
| 3 | 102 | 0.40 | 0.77 | 19 | empty |
| 4 | 146 | 0.40 | 0.74 | 23 | empty |
| 5 | 80 | 0.39 | 0.78 | 27 | empty |
Interfaces
12 interfaces between chains.
- D–H · 1152 Ų buried · 32 hydrogen bonds · protein-protein
- A–E · 1143 Ų buried · 35 hydrogen bonds · protein-protein
- A–C · 997 Ų buried · 14 hydrogen bonds · protein-protein
- B–F · 897 Ų buried · 25 hydrogen bonds · protein-protein
- C–G · 887 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 5WTB · Complex Structure of Staphylococcus aureus SdrE with human complement factor H · the same entry in another collection · chain H against H, TM-score 1.00
- Q932F7 · AlphaFold monomer V2.0 prediction for serine-aspartate repeat- containing protein E… · a predicted model of the same protein · chain D against A, TM-score 0.98
- P08603 · AlphaFold monomer V2.0 prediction for complement factor H (P08603) · a predicted model of the same protein · chain F against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q932F7
- Every structure of UniProt P08603
- Elsewhere: RCSB PDB 5WTB · PDBe 5WTB · UniProt Q932F7 · UniProt P08603
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.