Research workbench
MU2 subunit of the clathrin adaptor complex AP2 in complex with irs-1 Y658 peptide
Analyse MU2 subunit of the clathrin adaptor complex AP2 in complex with irs-1 Y658… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WRM
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit mu; Insulin receptor substrate 1
- UniProt
- P84092, P35570
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit mu | protein | 259 | 3% helix, 56% strand | P84092 |
| P | Insulin receptor substrate 1 | protein | 6 | 0% helix, 33% strand | P35570 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.52 | 0.80 | 32 | empty |
| 2 | 100 | 0.38 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–P · 408 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5WRM · Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y658 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P84092 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P35570 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 1 (P35570) · a predicted model of the same protein · chain P against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84092
- Every structure of UniProt P35570
- Elsewhere: RCSB PDB 5WRM · PDBe 5WRM · UniProt P84092 · UniProt P35570
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