Research workbench

Thermolysin, sfx liganded form with oil-based carrier

Analyse Thermolysin, sfx liganded form with oil-based carrier in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WR2
Type: protein
Length: 316 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thermolysin
EC: 3.4.24.27
UniProt: P43133
Ligands: NX6, CA, ZN
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thermolysin (EC 3.4.24.27)	protein	316	41% helix, 18% strand	P43133

Ligands and binding sites

NX6 · N-[(benzyloxy)carbonyl]-L-aspartic acid · ligand · chains A
CA · Calcium ion · metal · 4 copies · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	133	0.51	0.80	24	NX6, ZN

Compared structures

5WR2 · Thermolysin, SFX liganded form with oil-based carrier · the same entry in another collection · chain A against A, TM-score 1.00
P43133 · AlphaFold monomer V2.0 prediction for thermolysin (P43133) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43133
Elsewhere: RCSB PDB 5WR2 · PDBe 5WR2 · UniProt P43133

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