Research workbench
Structure of NS3 from HCV strain jfh-1 that is an unusually robust helicase that is primed to bind and unwind viral RNA
Analyse Structure of NS3 from HCV strain jfh-1 that is an unusually robust helicase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WDX
- Type
- protein
- Length
- 642 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Jfh-1 NS3
- UniProt
- R9TEU1
- Ligands
- MG, ZN
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Jfh-1 NS3 | protein | 642 | 28% helix, 30% strand | R9TEU1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 694 | 0.79 | 0.84 | 71 | empty |
| 2 | 268 | 0.67 | 0.84 | 37 | MG |
| 3 | 165 | 0.48 | 0.77 | 23 | empty |
| 4 | 125 | 0.40 | 0.75 | 17 | empty |
| 5 | 54 | 0.39 | 0.81 | 12 | empty |
Compared structures
- 5WDX · Structure of NS3 from HCV strain JFH-1 that is an unusually robust helicase that is… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R9TEU1
- Elsewhere: RCSB PDB 5WDX · PDBe 5WDX · UniProt R9TEU1
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