Research workbench
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
Analyse An ultra-stable single-chain insulin analog resists thermal inactivation and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WDM
- Type
- protein
- Length
- 273 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Single-chain insulin analog
- UniProt
- A6XGL2
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Single-chain insulin analog | protein | 45 | 49% helix, 9% strand | A6XGL2 |
| B | Single-chain insulin analog | protein | 46 | 50% helix, 9% strand | A6XGL2 |
| C, F | Single-chain insulin analog | protein | 44 | 48% helix, 9% strand | A6XGL2 |
| D, E | Single-chain insulin analog | protein | 47 | 49% helix, 9% strand | A6XGL2 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 268 | 0.60 | 0.79 | 30 | empty |
| 2 | 82 | 0.51 | 0.83 | 21 | empty |
| 3 | 164 | 0.49 | 0.77 | 23 | empty |
| 4 | 148 | 0.45 | 0.76 | 26 | empty |
| 5 | 89 | 0.43 | 0.78 | 12 | empty |
Interfaces
13 interfaces between chains.
- E–F · 588 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 514 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 502 Ų buried · 5 hydrogen bonds · protein-protein
- A–F · 493 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 387 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 5WDM · An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6XGL2
- Elsewhere: RCSB PDB 5WDM · PDBe 5WDM · UniProt A6XGL2
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