Research workbench
P130CAS complex with paxillin LD1
Analyse P130CAS complex with paxillin LD1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5W93
- Type
- protein
- Length
- 417 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Breast cancer anti-estrogen resistance protein 1; Paxillin
- UniProt
- Q61140, Q8VI36
- Pockets
- 5 · best druggability 0.45
Structure
x-ray diffraction · 5 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Breast cancer anti-estrogen resistance protein 1 | protein | 133 | 90% helix, 0% strand | Q61140 |
| C | Breast cancer anti-estrogen resistance protein 1 | protein | 116 | 87% helix, 0% strand | Q61140 |
| D | Paxillin | protein | 12 | 50% helix, 0% strand | Q8VI36 |
| E | Paxillin | protein | 13 | 62% helix, 0% strand | Q8VI36 |
| F | Paxillin | protein | 10 | 80% helix, 0% strand | Q8VI36 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.45 | 0.79 | 16 | empty |
| 2 | 139 | 0.41 | 0.74 | 21 | empty |
| 3 | 54 | 0.35 | 0.78 | 13 | empty |
| 4 | 64 | 0.30 | 0.75 | 10 | empty |
| 5 | 56 | 0.30 | 0.76 | 16 | empty |
Interfaces
8 interfaces between chains.
- A–D · 592 Ų buried · 6 hydrogen bonds · protein-protein
- B–E · 584 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 480 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 449 Ų buried · 7 hydrogen bonds · protein-protein
- C–F · 426 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5W93 · p130Cas complex with paxillin LD1 · the same entry in another collection · chain F against F, TM-score 1.00
- Q61140 · AlphaFold monomer V2.0 prediction for breast cancer anti-estrogen resistance protein 1… · a predicted model of the same protein · chain B against A, TM-score 1.00
- Q8VI36 · AlphaFold monomer V2.0 prediction for paxillin (Q8VI36) · a predicted model of the same protein · chain F against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61140
- Every structure of UniProt Q8VI36
- Elsewhere: RCSB PDB 5W93 · PDBe 5W93 · UniProt Q61140 · UniProt Q8VI36
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