Research workbench
Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1C
Analyse Crystal structure of a monomeric human FGF9 in complex with the ectodomain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5W59
- Type
- protein
- Length
- 354 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 9; Fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P31371, P11362
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor 9 | protein | 146 | 10% helix, 43% strand | P31371 |
| B | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 208 | 6% helix, 52% strand | P11362 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.49 | 0.77 | 25 | empty |
| 2 | 104 | 0.43 | 0.78 | 16 | empty |
| 3 | 79 | 0.43 | 0.80 | 22 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1445 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 5W59 · Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c · the same entry in another collection · chain A against A, TM-score 1.00
- P31371 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 9 (P31371) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31371
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 5W59 · PDBe 5W59 · UniProt P31371 · UniProt P11362
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