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Human kallikrein 6 (HK6) active form with benzamidine inhibitor at 1.56 a resolution

Analyse Human kallikrein 6 (HK6) active form with benzamidine inhibitor at 1.56 a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LO6
Type: protein
Length: 221 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kallikrein 6
UniProt: Q92876
Ligands: BEN, MG
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kallikrein 6	protein	221	10% helix, 38% strand	Q92876

Ligands and binding sites

BEN · Benzamidine · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.37	0.77	20	BEN

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1LO6 · Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q92876 · AlphaFold monomer V2.0 prediction for kallikrein-6 (Q92876) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92876
Elsewhere: RCSB PDB 1LO6 · PDBe 1LO6 · UniProt Q92876

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