UniProt Q92876
Kallikrein-6 (Q92876)
Kallikrein-6 (UniProt Q92876), EC 3.4.21.-: 25 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q92876
- Protein
- Kallikrein-6
- EC
- 3.4.21.-
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 3 · 2 records with a druggable one
Structures
26 records of Q92876 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GVL | Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin | x-ray diffraction | A | — | — |
| 1GVL | Human prokallikrein 6 (HK6)/ prozyme/ proprotease M/ proneurosin | x-ray diffraction | A | — | — |
| 1L2E | Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor | x-ray diffraction | A | — | — |
| 1L2E | Human kallikrein 6 (HK6) active form with benzamidine inhibitor | x-ray diffraction | A | — | — |
| 1LO6 | Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution | x-ray diffraction | A | — | — |
| 1LO6 | Human kallikrein 6 (HK6) active form with benzamidine inhibitor at 1.56 a resolution | x-ray diffraction | A | — | — |
| 3VFE | Virtual Screening and X-Ray Crystallography for Human Kallikrein 6 Inhibitors with an… | x-ray diffraction | A | — | — |
| 3VFE | Virtual screening and X-ray crystallography for human kallikrein 6 inhibitors with an… | x-ray diffraction | A | — | — |
| 4D8N | Human Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency | x-ray diffraction | A | — | — |
| 4D8N | Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group carry a high binding efficiency | x-ray diffraction | A | — | — |
| 5NX1 | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human… | x-ray diffraction | A | — | — |
| 5NX1 | Combinatorial engineering of proteolytically resistant appi variants that selectively inhibit human… | x-ray diffraction | A | — | — |
| 5NX3 | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human… | x-ray diffraction | A | — | 2 (best 0.55) |
| 5NX3 | Combinatorial engineering of proteolytically resistant appi variants that selectively inhibit human… | x-ray diffraction | A | — | — |
| 6QFF | Crystal structure of human kallikrein 6 in complex with GSK144 | x-ray diffraction | A, B | J08 | — |
| 6QFG | Crystal structure of human kallikrein 6 (I218Y) in complex with GSK144 | x-ray diffraction | A, B | J08 | — |
| 6QFH | Crystal structure of human kallikrein 6 (N217D/I218Y/K224R) in complex with GSK144. | x-ray diffraction | A, B | J08 | — |
| 6QH9 | Crystal structure of human kallikrein 6 in complex with GSK3239861A | x-ray diffraction | A, B | UNX, J2N, J3B | — |
| 6QHA | Crystal structure of human kallikrein 6 in complex with GSK3205388B | x-ray diffraction | A, B | UNX, J2Q | — |
| 6QHB | Crystal structure of human kallikrein 6 in complex with GSK578724A | x-ray diffraction | A, B | J2W | — |
| 6QHC | Crystal structure of human kallikrein 6 in complex with GSK358180B | x-ray diffraction | A, B | 135 | — |
| 6SKB | Crystal structure of human kallikrein 6 (N217D/I218Y/K224R) in complex with GSK3496783A | x-ray diffraction | A, B, C | LH5, RH5 | — |
| 6SKC | Crystal structure of human kallikrein 6 (I218Y) in complex with GSK3448330A | x-ray diffraction | A, B | LH8, BEN | — |
| 6SKD | Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3397892A | x-ray diffraction | A, B | UNX, LH2 | 1 (best 0.72) |
| 6SKD | Crystal structure of human kallikrein 6 (I218Y) in complex with GSK3397892A | x-ray diffraction | A, B | UNX, LH2 | — |
| Q92876 | AlphaFold monomer V2.0 prediction for kallikrein-6 (Q92876) | predicted | A | — | — |
Ligands
- UNX · Unknown atom or ion · in 4 records
- J08 · 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide · in 3 records
- LH2 · 4-[[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]methylamino]benzenecarboximidamide · in 2 records
- 135 · N-(4-carbamimidoyl-phenyl)-2-hydroxy-benzamide · in 1 record
- BEN · Benzamidine · in 1 record
- J2N · (3~{S})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide · in 1 record
- J2Q · ~{N}-(4-carbamimidoylphenyl)-3-ethoxy-2-oxidanyl-benzamide · in 1 record
- J2W · ~{N}-(4-carbamimidoylphenyl)-3-methoxy-2-oxidanyl-benzamide · in 1 record
- J3B · (3~{R})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide · in 1 record
- LH5 · 4-[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide · in 1 record
- LH8 · 4-[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]benzenecarboximidamide · in 1 record
- RH5 · 4-[(3~{R})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide · in 1 record
Experiment against prediction
- 6QFF chain B against the predicted model Q92876: TM-score 1.00, RMSD 0.28 Å
- 6QFG chain B against the predicted model Q92876: TM-score 1.00, RMSD 0.28 Å
- 6QHA chain B against the predicted model Q92876: TM-score 1.00, RMSD 0.30 Å
- 6QHC chain A against the predicted model Q92876: TM-score 1.00, RMSD 0.31 Å
- 6SKD chain B against the predicted model Q92876: TM-score 1.00, RMSD 0.34 Å
- 6QHB chain B against the predicted model Q92876: TM-score 1.00, RMSD 0.36 Å
- 5NX1 chain A against the predicted model Q92876: TM-score 1.00, RMSD 0.35 Å
- 5NX1 chain A against the predicted model Q92876: TM-score 1.00, RMSD 0.35 Å
- 6QH9 chain B against the predicted model Q92876: TM-score 1.00, RMSD 0.36 Å
- 1L2E chain A against the predicted model Q92876: TM-score 1.00, RMSD 0.36 Å
Elsewhere
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