Research workbench
Molecular structure of fus low sequence complexity domain protein fibrils
Analyse Molecular structure of fus low sequence complexity domain protein fibrils in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5W3N
- Type
- protein
- Length
- 549 residues
- Chains
- 9
- Method
- solid-state nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein fus
- UniProt
- P35637
- Pockets
- 1 · best druggability 0.40
Structure
solid-state nmr · 1 distinct chain · 0% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | RNA-binding protein fus | protein | 61 | 0% helix, 33% strand | P35637 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.40 | 0.77 | 28 | empty |
Interfaces
15 interfaces between chains.
- E–F · 2325 Ų buried · 90 hydrogen bonds · protein-protein
- D–E · 2322 Ų buried · 90 hydrogen bonds · protein-protein
- F–G · 2322 Ų buried · 91 hydrogen bonds · protein-protein
- G–H · 2320 Ų buried · 91 hydrogen bonds · protein-protein
- C–D · 2320 Ų buried · 91 hydrogen bonds · protein-protein
Compared structures
- 5W3N · Molecular structure of FUS low sequence complexity domain protein fibrils · the same entry in another collection · chain I against I, TM-score 1.00
- P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain I against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 5W3N · PDBe 5W3N · UniProt P35637
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