BRD4-BD1 in complex with CPD19 (3-(7-(difluoromethyl)-6-(1-methyl-1H- pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro- 2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-PYRAZOLO[4,3-C]PYRIDINE-5- carboxamide)

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• 9U4 · 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4, 6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide · ligand · 2 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5VZS · BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dih… · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

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• Every structure of UniProt O60885
• Elsewhere: RCSB PDB 5VZS · PDBe 5VZS · UniProt O60885