Research workbench
Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide ac-ptyr-glu-glu-gly (pyeeg peptide)
Analyse Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LKL
- Type
- protein
- Length
- 108 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human P56 tyrosine kinase; Phosphotyrosyl peptide ac-ptyr-glu-glu-gly
- UniProt
- P06239
- Ligands
- ACE
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human P56 tyrosine kinase | protein | 104 | 17% helix, 29% strand | P06239 |
| B | Phosphotyrosyl peptide ac-ptyr-glu-glu-gly | protein | 4 | 0% helix, 25% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 428 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 1LKL · Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide… · the same entry in another collection · chain A against A, TM-score 1.00
- P06239 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase lck (P06239) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06239
- Elsewhere: RCSB PDB 1LKL · PDBe 1LKL · UniProt P06239
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