Research workbench
Crystal structure of cell division protein ftsz from mycobacterium tuberculosis bounded via the T9 loop
Analyse Crystal structure of cell division protein ftsz from mycobacterium tuberculosis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5V68
- Type
- protein
- Length
- 1,671 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein ftsz
- UniProt
- A5U4H7
- Ligands
- GDP, PO4
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 6 distinct chains · 38% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division protein ftsz | protein | 263 | 29% helix, 6% strand | A5U4H7 |
| B | Cell division protein ftsz | protein | 301 | 44% helix, 18% strand | A5U4H7 |
| C | Cell division protein ftsz | protein | 297 | 36% helix, 19% strand | A5U4H7 |
| D | Cell division protein ftsz | protein | 212 | 31% helix, 16% strand | A5U4H7 |
| E | Cell division protein ftsz | protein | 298 | 42% helix, 17% strand | A5U4H7 |
| F | Cell division protein ftsz | protein | 300 | 43% helix, 17% strand | A5U4H7 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, E
- PO4 · Phosphate ion · ion · 2 copies · chains C, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.81 | 0.93 | 48 | PO4 |
| 2 | 317 | 0.80 | 0.91 | 50 | PO4 |
| 3 | 61 | 0.72 | 0.98 | 21 | empty |
| 4 | 461 | 0.62 | 0.76 | 57 | empty |
| 5 | 187 | 0.62 | 0.83 | 25 | empty |
Interfaces
7 interfaces between chains.
- B–C · 1171 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 1052 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 722 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 598 Ų buried · 3 hydrogen bonds · protein-protein
- B–F · 248 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5V68 · Crystal structure of cell division protein FtsZ from Mycobacterium tuberculosis bounded… · the same entry in another collection · chain F against F, TM-score 1.00
- A5U4H7 · AlphaFold monomer V2.0 prediction for cell division protein ftsz (A5U4H7) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5U4H7
- Elsewhere: RCSB PDB 5V68 · PDBe 5V68 · UniProt A5U4H7
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