Research workbench
Crystal structure of calcium-depleted human C-reactive protein from perfectly twinned data
Analyse Crystal structure of calcium-depleted human C-reactive protein from perfectly… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LJ7
- Type
- protein
- Length
- 2,015 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C-reactive protein
- UniProt
- P02741
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 5 distinct chains · 8% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, I | C-reactive protein | protein | 199 | 8% helix, 46% strand | P02741 |
| B, F, G, J | C-reactive protein | protein | 206 | 9% helix, 44% strand | P02741 |
| C | C-reactive protein | protein | 199 | 8% helix, 46% strand | P02741 |
| D, E | C-reactive protein | protein | 197 | 8% helix, 46% strand | P02741 |
| H | C-reactive protein | protein | 200 | 8% helix, 46% strand | P02741 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 956 | 0.74 | 0.77 | 105 | empty |
| 2 | 732 | 0.69 | 0.76 | 92 | empty |
| 3 | 660 | 0.68 | 0.76 | 93 | empty |
| 4 | 523 | 0.66 | 0.77 | 64 | empty |
| 5 | 278 | 0.65 | 0.82 | 39 | empty |
Interfaces
15 interfaces between chains.
- A–B · 699 Ų buried · 9 hydrogen bonds · protein-protein
- I–J · 697 Ų buried · 7 hydrogen bonds · protein-protein
- D–E · 695 Ų buried · 9 hydrogen bonds · protein-protein
- H–I · 694 Ų buried · 7 hydrogen bonds · protein-protein
- F–G · 692 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1LJ7 · Crystal structure of calcium-depleted human C-reactive protein from perfectly twinned data · the same entry in another collection · chain J against J, TM-score 1.00
- P02741 · AlphaFold monomer V2.0 prediction for C-reactive protein (P02741) · a predicted model of the same protein · chain H against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02741
- Elsewhere: RCSB PDB 1LJ7 · PDBe 1LJ7 · UniProt P02741
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