Human bfl-1 in complex with puma BH3

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains B
• NH2 · Amino group · ion · chains B
• SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 1004 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 5UUL · Human Bfl-1 in complex with PUMA BH3 · the same entry in another collection · chain A against A, TM-score 1.00
• Q16548 · AlphaFold monomer V2.0 prediction for BCL-2-related protein A1 (Q16548) · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q9BXH1 · AlphaFold monomer V2.0 prediction for BCL-2-binding component 3, isoforms 1/2 (Q9BXH1) · a predicted model of the same protein · chain B against A, TM-score 0.61

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q16548
• Every structure of UniProt Q9BXH1
• Elsewhere: RCSB PDB 5UUL · PDBe 5UUL · UniProt Q16548 · UniProt Q9BXH1