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Crystal structure of mutant ig-like domain

Analyse Crystal structure of mutant ig-like domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5UD8
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triggering receptor expressed on myeloid cells 2
UniProt: Q9NZC2
Pockets: 1 · best druggability 0.28

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Triggering receptor expressed on myeloid cells 2	protein	106	8% helix, 55% strand	Q9NZC2
B	Triggering receptor expressed on myeloid cells 2	protein	104	3% helix, 57% strand	Q9NZC2

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.28	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 331 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5UD8 · Crystal Structure of Mutant Ig-like Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9NZC2 · AlphaFold monomer V2.0 prediction for triggering receptor expressed on myeloid cells 2… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZC2
Elsewhere: RCSB PDB 5UD8 · PDBe 5UD8 · UniProt Q9NZC2

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