UniProt Q9NZC2
Triggering receptor expressed on myeloid cells 2 (Q9NZC2)
Triggering receptor expressed on myeloid cells 2 (UniProt Q9NZC2): 22 experimental structures on GenesisL1, 6 ligands bound, 32 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9NZC2
- Protein
- Triggering receptor expressed on myeloid cells 2
- Experimental structures
- 22
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 32 · 4 records with a druggable one
Structures
22 records of Q9NZC2 in the MolNFT archive: 22 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ELI | Triggering receptor expressed on myeloid cells 2 | x-ray diffraction | A, B | NAG | — |
| 5ELI | Triggering receptor expressed on myeloid cells 2 | x-ray diffraction | A, B | — | — |
| 5UD7 | Crystal Structure of Wild-Type Ig-like Domain | x-ray diffraction | A, B, C, D, E, F | NAG, IOD, SO4 | — |
| 5UD7 | Crystal structure of wild-type ig-like domain | x-ray diffraction | A, B, C, D, E, F | NAG, IOD, SO4 | — |
| 5UD8 | Crystal Structure of Mutant Ig-like Domain | x-ray diffraction | A, B | — | 1 (best 0.28) |
| 5UD8 | Crystal structure of mutant ig-like domain | x-ray diffraction | A, B | — | — |
| 6B8O | Wt ig-like V domain with phosphatidylserine | x-ray diffraction | A, B, C, D, E, F | NAG, IOD, SO4 | — |
| 6XDS | Crystal structure of MBP-TREM2 Ig domain fusion with fragment, 2-((4-bromophenyl)amino)ethan-1-ol | x-ray diffraction | A | GLC, V5S | 5 (best 0.75) |
| 6XDS | Crystal structure of mbp-TREM2 ig domain fusion with fragment, 2-((4- BROMOPHENYL)AMINO)ETHAN-1-ol | x-ray diffraction | A | GLC, V5S | — |
| 6Y6C | TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4) | x-ray diffraction | A, B | NAG | 5 (best 0.43) |
| 6Y6C | TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scfv-4) | x-ray diffraction | A, B | NAG | — |
| 6YMQ | TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) | x-ray diffraction | G, H, I, J, K, D000 | NAG | 12 (best 0.66) |
| 6YYE | TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2) | x-ray diffraction | A, B | NAG | 6 (best 0.39) |
| 6YYE | TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scfv-2) | x-ray diffraction | A, B | NAG | — |
| 6Z0G | Structure of TREM2 transmembrane helix in DPC micelles | solution nmr | A | — | — |
| 6Z0G | Structure of TREM2 transmembrane helix in dpc micelles | solution nmr | A | — | — |
| 6Z0H | Structure of TREM2 transmembrane helix K186A variant in DPC micelles | solution nmr | A | — | — |
| 6Z0H | Structure of TREM2 transmembrane helix K186A variant in dpc micelles | solution nmr | A | — | — |
| 6Z0I | Structure of the TREM2 transmembrane helix in complex with DAP12 in dpc micelles | solution nmr | A | — | — |
| 8T51 | Crystal structure of Fab 3.10C2 bound to TREM2 | x-ray diffraction | E, F | SO4, ZN | 2 (best 0.78) |
| 8T59 | Crystal structure of Para.09 bound to TREM2 | x-ray diffraction | E, F | ZN | 1 (best 0.77) |
| Q9NZC2 | AlphaFold monomer V2.0 prediction for triggering receptor expressed on myeloid cells 2 (Q9NZC2) | — | — | — |
Ligands
Elsewhere
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