Research workbench
TREX2 M-region
Analyse TREX2 M-region in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UBP
- Type
- protein
- Length
- 972 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine permease transcriptional regulator; Nuclear mRNA export protein THP1; 26S…
- UniProt
- B3LGC5, Q08231, O94742
- Pockets
- 20 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 59% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine permease transcriptional regulator | protein | 469 | 54% helix, 3% strand | B3LGC5 |
| B | Nuclear mRNA export protein THP1 | protein | 455 | 65% helix, 2% strand | Q08231 |
| C | 26S proteasome complex subunit SEM1 | protein | 48 | 42% helix, 2% strand | O94742 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.68 | 0.76 | 71 | empty |
| 2 | 350 | 0.61 | 0.78 | 39 | empty |
| 3 | 84 | 0.60 | 0.88 | 24 | empty |
| 4 | 187 | 0.53 | 0.78 | 22 | empty |
| 5 | 128 | 0.52 | 0.81 | 22 | empty |
Interfaces
2 interfaces between chains.
- A–B · 4054 Ų buried · 49 hydrogen bonds · protein-protein
- B–C · 2414 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5UBP · TREX2 M-region · the same entry in another collection · chain A against A, TM-score 1.00
- Q08231 · AlphaFold monomer V2.0 prediction for nuclear mRNA export protein THP1 (Q08231) · a predicted model of the same protein · chain B against A, TM-score 0.98
- O94742 · AlphaFold monomer V2.0 prediction for 26S proteasome complex subunit SEM1 (O94742) · a predicted model of the same protein · chain C against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B3LGC5
- Every structure of UniProt Q08231
- Every structure of UniProt O94742
- Elsewhere: RCSB PDB 5UBP · PDBe 5UBP · UniProt B3LGC5 · UniProt Q08231 · UniProt O94742
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