UniProt O94742
26S proteasome complex subunit SEM1 (O94742)
26S proteasome complex subunit SEM1 (UniProt O94742): 47 experimental structures and 1 predicted model on GenesisL1, 51 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O94742
- Protein
- 26S proteasome complex subunit SEM1
- Experimental structures
- 47
- Predicted models
- 1
- Pockets
- 51 · 16 records with a druggable one
Structures
48 records of O94742 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCK | Structure of the yeast 26S proteasome lid sub-complex | electron microscopy | I | — | 3 (best 0.78) |
| 3JCK | Structure of the yeast 26S proteasome lid sub-complex | electron microscopy | I | — | — |
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | Y | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | Y | — | — |
| 3T5V | Sac3:Thp1:Sem1 complex | x-ray diffraction | C, F | — | 8 (best 0.85) |
| 3T5V | SAC3:THP1:SEM1 complex | x-ray diffraction | C, F | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Y | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Y | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Y | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Y | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Y | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Y | — | — |
| 4TRQ | Crystal structure of Sac3/Thp1/Sem1 | x-ray diffraction | C, F | — | 8 (best 0.59) |
| 4TRQ | Crystal structure of SAC3/THP1/SEM1 | x-ray diffraction | C, F | — | — |
| 5A5B | Structure of the 26S proteasome-Ubp6 complex | electron microscopy | Y | — | — |
| 5A5B | Structure of the 26S proteasome-UBP6 complex | electron microscopy | Y | — | — |
| 5G5P | Structure of the Saccharomyces cerevisiae TREX-2 complex | electron microscopy | C | — | 6 (best 0.54) |
| 5G5P | Structure of the saccharomyces cerevisiae trex-2 complex | electron microscopy | C | — | — |
| 5L3T | Structure of the Saccharomyces cerevisiae TREX-2 complex | x-ray diffraction | C | — | 6 (best 0.53) |
| 5L3T | Structure of the saccharomyces cerevisiae trex-2 complex | x-ray diffraction | C | — | — |
| 5MPB | 26S proteasome in presence of AMP-PNP (s3) | electron microscopy | Y | — | 1 (best 0.78) |
| 5MPC | 26S proteasome in presence of BeFx (s4) | electron microscopy | Y | — | 1 (best 0.79) |
| 5MPD | 26S proteasome in presence of ATP (s1) | electron microscopy | Y | — | 2 (best 0.81) |
| 5MPD | 26S proteasome in presence of ATP (S1) | electron microscopy | Y | — | — |
| 5MPE | 26S proteasome in presence of ATP (s2) | electron microscopy | Y | — | 3 (best 0.79) |
| 5MPE | 26S proteasome in presence of ATP (S2) | electron microscopy | Y | — | — |
| 5UBP | TREX2 M-region | x-ray diffraction | C | — | 5 (best 0.53) |
| 5UBP | TREX2 M-region | x-ray diffraction | C | — | — |
| 5WVI | The resting state of yeast proteasome | electron microscopy | Y | — | 1 (best 0.80) |
| 5WVK | Yeast proteasome-ADP-AlFx | electron microscopy | Y | — | — |
| 6FVT | 26S proteasome, s1 state | electron microscopy | Y | — | 1 (best 0.78) |
| 6FVU | 26S proteasome, s2 state | electron microscopy | Y | — | — |
| 6FVV | 26S proteasome, s3 state | electron microscopy | Y | — | 1 (best 0.82) |
| 6FVW | 26S proteasome, s4 state | electron microscopy | Y | — | — |
| 6FVX | 26S proteasome, s5 state | electron microscopy | Y | — | 1 (best 0.78) |
| 6FVY | 26S proteasome, s6 state | electron microscopy | Y | — | 1 (best 0.75) |
| 6J2C | Yeast proteasome in translocation competent state (C3-a) | electron microscopy | Y | — | — |
| 6J2N | yeast proteasome in substrate-processing state (C3-b) | electron microscopy | Y | — | — |
| 6J2Q | Yeast proteasome in Ub-accepted state (C1-b) | electron microscopy | Y | — | — |
| 6J2X | Yeast proteasome in resting state (C1-a) | electron microscopy | Y | — | — |
| 6J30 | yeast proteasome in Ub-engaged state (C2) | electron microscopy | Y | — | — |
| 7EWF | Selenomethionine-substituted structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1 | x-ray diffraction | C | — | — |
| 7EWM | Native crystal structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1 | x-ray diffraction | C | — | — |
| 7QO3 | Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid) | electron microscopy | Y | — | 3 (best 0.75) |
| 7QO3 | Structure of the 26S proteasome-UBP6 complex in the si state (core particle and lid) | electron microscopy | Y | — | — |
| 7QO5 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | electron microscopy | Y | — | — |
| 7QO6 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state | electron microscopy | Y | — | — |
| O94742 | AlphaFold monomer V2.0 prediction for 26S proteasome complex subunit SEM1 (O94742) | predicted | A | — | — |
Experiment against prediction
- 4CR2 chain Y against the predicted model O94742: TM-score 0.66, RMSD 0.41 Å
- 4CR2 chain Y against the predicted model O94742: TM-score 0.66, RMSD 0.41 Å
- 4CR4 chain Y against the predicted model O94742: TM-score 0.66, RMSD 0.41 Å
- 4CR4 chain Y against the predicted model O94742: TM-score 0.66, RMSD 0.41 Å
- 4CR3 chain Y against the predicted model O94742: TM-score 0.64, RMSD 0.45 Å
- 4CR3 chain Y against the predicted model O94742: TM-score 0.64, RMSD 0.45 Å
- 5A5B chain Y against the predicted model O94742: TM-score 0.64, RMSD 0.45 Å
- 5A5B chain Y against the predicted model O94742: TM-score 0.64, RMSD 0.45 Å
- 5WVI chain Y against the predicted model O94742: TM-score 0.54, RMSD 1.13 Å
- 3T5V chain F against the predicted model O94742: TM-score 0.54, RMSD 2.67 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.