MolNFT v2 · #180070 · protein
Native crystal structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1
7EWM · Protein THP3: “Native crystal structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1”. X-ray diffraction at 2.9, 10 pockets (best druggability 0.71). MolNFT v2 #180070 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7EWM
- Type
- protein
- Length
- 739 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Saccharomyces cerevisiae S288C
- Molecule
- Protein THP3; Cop9 signalosome complex subunit 12; 26S proteasome complex subunit SEM1
- UniProt
- Q12049, P47130, O94742
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · resolution 2.9 · 3 distinct chains · 61% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein THP3 | protein | 272 | 62% helix, 6% strand | Q12049 |
| B | Cop9 signalosome complex subunit 12 | protein | 409 | 64% helix, 4% strand | P47130 |
| C | 26S proteasome complex subunit SEM1 | protein | 58 | 33% helix, 5% strand | O94742 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 776 | 0.71 | 0.77 | 68 | empty |
| 2 | 454 | 0.66 | 0.78 | 46 | empty |
| 3 | 232 | 0.64 | 0.82 | 25 | empty |
| 4 | 184 | 0.60 | 0.82 | 29 | empty |
| 5 | 344 | 0.57 | 0.76 | 37 | empty |
Interfaces
2 interfaces between chains.
- B–C · 2678 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 1244 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- Q12049 · AlphaFold monomer V2.0 prediction for protein THP3 (Q12049) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P47130 · AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 12 (P47130) · a predicted model of the same protein · chain B against A, TM-score 0.95
- O94742 · AlphaFold monomer V2.0 prediction for 26S proteasome complex subunit SEM1 (O94742) · a predicted model of the same protein · chain C against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12049
- Every structure of UniProt P47130
- Every structure of UniProt O94742
- Elsewhere: RCSB PDB 7EWM · PDBe 7EWM · UniProt Q12049 · UniProt P47130 · UniProt O94742
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